mebeverine and omeprazole together methotrexate

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Accumulating evidence WebThere are 280 drugs known to interact with tamsulosin, along with 4 disease interactions, and 2 alcohol/food interactions. Unable to load your collection due to an error, Unable to load your delegates due to an error. It is based on mebeverine hydrochloride and methotrexate sodium (the active ingredients of Mebeverine hydrochloride and Methotrexate, respectively), and Mebeverine hydrochloride and Methotrexate (the brand names). Prescribers should continue to follow recommendations in the The renal hydrogen/potassium adenosine triphosphatase (H+/K(+)-ATPase) pump makes the urine more acidic, by secreting hydrogen ions into the renal tubule and reabsorbing potassium ions. It is based on omeprazole and methotrexate sodium (the active ingredients of Prilosec and Methotrexate, respectively), and Prilosec and Methotrexate (the brand names). Concomitant use of methotrexate and proton pump inhibitors (PPIs) may increase Phenytoin omeprazole and esomeprazole can occasionally enhance the effects of phenytoin. This content does not have an English version. A combination of oral azathioprine and methotrexate in difficult to treat dermatoses. Medsafe are currently working with the relevant pharmaceutical companies Since some people may need to take a seizure medication as well as methotrexate, it may be comforting to know that some epilepsy medications dont pose a severe or moderate risk when taken with the drug. Anticonvulsants that are safe to take while on methotrexate include: 13 HHS Vulnerability Disclosure, Help All rights reserved. Some people who take methotrexate will need to take folic acid supplements because the medication can diminish the amount of folate in the body. Potentially, but Ive taken omeprazole since diagnosis in 2008 & MTX the year after & my kidneys haven't reacted. Ann Pharmacother. Omeprazole can inhibit renal elimination of the hydrogen ion and block the active tubular secretion of MTX. All of the patients involved were MTX for osteosarcoma. Site Map, 0 Then As you have regimen containing both the drug taken along with metronidazole. I can't say Ive been specifically told about the Santucci R, Leveque D, Lescoute A, et al. Active tubular secretion of MTX requires the activity of this pump because MTX is excreted with hydrogen ions. Some PPIs are available over-the-counter. pump inhibitors delays elimination of plasma methotrexate in high-dose Objective: Epub 2014 Sep 19. Proton Pump Inhibitors (PPIs) These drugs, such as Prilosec (omeprazole), Nexium (esomeprazole), Prevacid (lansoprazole), and Protonix (pantoprazole), are used to treat acid reflux. with methotrexate possibly associated with concomitant use of proton All rights reserved. Some research suggests that it can limit the efficacy of methotrexate, while others have found that adding caffeine to a treatment plan can actually reduce symptoms of methotrexate intolerance. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. The site is secure. Delayed elimination of methotrexate by cola beverages in a pediatric acute lymphoblastic leukemia population. other information we have about you. Liver diseaseUse with caution. Indian J Dermatol Venereol Leprol. We study millions of patients and 5,000 more each day. I ended up with gastritis (a precursor to ulcers) because I was given Pred 10 years ago for 2 weeks after a severe asthma attack any nsaids and you should take omeprozole/lanzoprazole omeprozole being the weaker dose of the two. %>, New Zealand Medicines and Medical WebOmeprazole is predicted to decrease the exposure to Gefitinib. Drug monitoring bloods keep an eye on our creatinine & urea levels so if there are any spikes it will be picked up. The only medication we suspected of inhibiting MTX elimination was omeprazole 20 mg every 12 hours. Bedoui Y, Guillot X, Slambarom J, et al. Using methotrexate over a long period of time has also been linked to liver conditions such as cirrhosis. Omeprazole has active ingredients of omeprazole. Reeves DJ, Moore ES, Bascom D, Rensing B. Br J Clin Pharmacol. Bezabeh S, Mackey AC, Kluetz P, et al. September 2013. Henien M, Carey B, Hullah E, Sproat C, Patel V. * Approximation only. Drugs that Impair Levothyroxine Absorption. The phase IV clinical study analyzes what interactions people who take Omeprazole and Methotrexate have. eHealthMe is studying from 168,989 Prilosec users for its effectiveness, alternative drugs and more. Hi all 2014 Dec;42(12):2041-8. doi: 10.1124/dmd.114.058529. Renzi S, Tsimerman E, Taylor T, Hopyan S, Koo A, Gupta A. J Pediatr Hematol Oncol. Versus Arthritis is registered with: Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Disclaimer. Good luck to you , hope you get sorted. Some mixtures of medications can lead to serious and even fatal consequences. MeSH It is in all guidelines that PPIs should be taken with any anti inflammatory medication- I have been on MTX for 30 odd years and numbers of times during that time when Ive been on steroids or NSAIDS I have always taken a PPI to protect my stomach. Im no expert, and I dont know if this helps, but when omeprazole didnt work for me my GP at the time tried changing dose, switching to lanzoprazole until finally I was put on pantoprazole which did work. PPI. About mebeverine Who 2023 eHealthMe.com. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. and transmitted securely. Ther Clin Risk Manag. A number of drugs have been shown to impair the absorption of levothyroxine; these drugs include calcium carbonate, aluminum- containing antacids, sucralfate, iron supplements, cholestyramine, sevelamer, and, possibly, ciprofloxacin, raloxifene, and orlistat. x, Thanks so much ML. pazopanib. itraconazole. Article Search Prescribers are asked to take care when high-dose methotrexate and PPIs sofosbuvir. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. . Omeprazole is a proton pump inhibitor (PPI). doi:10.1097/MD.0000000000005578, Levque D, Santucci R, Gourieux B, Herbrecht R. Pharmacokinetic drug-drug interactions with methotrexate in oncology. This is because too much methotrexate in the body can lead to toxic effects while antiviral medications are taken at the same time. Accumulating evidence for a drug-drug interaction between methotrexate and proton pump inhibitors. I take it first before my other meds. Potentially, but Ive taken omeprazole since diagnosis in 2008 & MTX the year after & my kidneys haven't reacted. PMC 2014 Feb;48(2):292-6. doi: 10.1177/1060028013511951. I don't know about interactions sorry. Stockleys With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Epub 2013 May 27. diseases. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. 2018 Jun 12;8(3):149-151. doi:10.1080/20009666.2018.1466598, Telles-Correia D, Barbosa A, Cortez-Pinto H, Campos C, Rocha NB, Machado S. Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity. You may opt-out of email communications at any time by clicking on Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of omeprazole in the elderly. for a drug-drug interaction between methotrexate and proton pump inhibitors. Anyway my point is you may not be on these forever. 3. information is beneficial, we may combine your email and website usage information with My mum had a hiatus hernia and used to take omeprazole too. I'll only be taking the prednisolone for label on them which says metoject has an interaction with omeprazole causing increased risk of comfortable with taking it so am after experience of anyone on here taking Omeprazole with 25mg people on MTX should not take it! 3. or by reporting directly to CARM (http://carm.otago.ac.nz/). When it comes to methotrexate, some foods or nutritional supplements can lead to adverse health effects or worsen the existing side effects of the drug. The problem is that it omeprazole (and other PPIs, like lansoprazole) affects how quickly you body processes the methotrexate, so it can potentially increase the toxicity. You have already got a sore tum so is there a choice? A deadly prescription: combination of methotrexate and trimethoprim-sulfamethoxazole. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists. MTX employed ranged from 15 to 20 grams, i.e. Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs. the levels of methotrexate in the blood and lead to adverse reactions. Drugs such as diclofenac ( Zorvolex) are more likely to affect the liver, so monitoring of the liver is recommended. Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity. Manufacturer advises caution. Summary Safety Review - Levetiracetam and Methotrexate - Assessing the Potential Risk of Drug-Drug Interaction. I think this bout of gastritis Im having was actually sparked by a recent short course of high does pred for an allergic reaction. Copyright 2023 IBM Watson Health. Discussion: government site. Potential Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. 2018 Aug;40(6):e392-e393. 2020 Oct;47(36). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Avoid combinations; the risk of the interaction outweighs the benefit. Your methotrexate dose can affect how severe some interactions are. With regard to the potential MTX / omeprazole interaction mentioned 2011 Nov;4(6):743-750. doi:10.1586/ecp.11.57. ketoconazole. The phase IV clinical study analyzes what interactions people who take Prilosec and Methotrexate have. After 10 years after going from Pantoprazole to ranitidine (which was suddenly withdrawn due to a cancer risk) I have finally weaned myself off and manage with just occasional Gaviscon tablets. No competing interests, Copyright 2023 BMJ Publishing Group Ltd, Womens, childrens & adolescents health. Thanks HH. Some medications, however, can interact with methotrexate and cause adverse effects. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. 2023 eHealthMe.com. Are you on 20mg omperazole, Hi Ruby. The best thing to do before starting a new treatment is discuss all your medications and supplements thoroughly with your healthcare provider to avoid drug interactions. 2012;17(4):550-4. doi: 10.1634/theoncologist.2011-0431. Of the total drug interactions, 32 are major, 244 are moderate, and 4 are minor. interaction between Methotrexate (MTX) and omeprazole was suspected, It is often used in rheumatoid arthritis. Beyond RA, methotrexate is also used in the treatment of severe psoriasis and some types of cancer, such as breast cancer, lung cancer, lymphoma, and leukemia. Enantioselective Drug Recognition by Drug Transporters. Adverse effects are caused by the antibiotic's ability to reduce methotrexate absorption in the body. Versus Arthritis was formed in 2018 following a merger of Arthritis Careand Arthritis Research UK. And, of course, there's a lot of information on our website for you to search through https://www.versusarthritis.org/. Other drugs that have the same active ingredients (e.g. Methotrexate has active ingredients of methotrexate sodium. Good luck and hope you settle down soon on whatever combination youre given. Registered Charity Nos. Most of us have had to take stomach protectors with prednisolone - and you should be on enteric coated for long term use - without any problems. Hi i have lupus and i believe it was my immune system itself that attacked my stomach. MTX is actively secreted in the distal tubules. Suspicion of drug-drug Dosage of drugs is not considered in the study. Omeprazole is widely prescribed to many people. WebMebeverine Brand names: Colofac, Colofac IBS, Aurobeverine Find out how mebeverine treats muscle spasms and stomach cramps, and how to take it. I think they can calm your stomach when its bad but they arent always added to your list forever. dose 1000 times lower still seems very dubious. Fraenkel L, Bathon JM, England BR, et al. official website and that any information you provide is encrypted pump inhibitors. We study millions of patients and 5,000 more each day. Your doctor or pharmacist may be able to offer suggestions on safer alternatives if you require treatment for stomach acid or ulcer while you are being treated with methotrexate. * Approximation only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Pharmacokinetic drug-drug interactions with methotrexate in oncology. If you need more assistance, please use the reply box below and let me Proton pump inhibitors inhibit methotrexate transport by renal basolateral organic anion transporter hOAT3. I have been on lanzoprazole for over 10 years had to go to up to esomeprozole because I was on Sulfasalazine but now Im off that I am back down and I am taking methotrexate by injection and have been on 30mg pred since august with 20mg before that since jan 2020. I always had the enteric coated ones and actually had no problem from steroids. Patients in the study may take other drugs besides Prilosec and Methotrexate. At a pH of approximately 5, as found in the renal tubules, pantoprazole is more slowly activated than omeprazole, reducing the incidence of unwanted reactions with sulfhydryl groups and adverse effects occurring outside of the gastric hydrogen pump. 2018 Nov 22;23(12):3062. doi: 10.3390/molecules23123062. All rights reserved. Versus Arthritis 2018. Omeprazole oral capsule is used for short-term treatment of duodenal and gastric ulcers and gastroesophageal reflux disease (GERD). Johns Hopkins Arthritis Center. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to relieve pain and decrease inflammation. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. PPIs are used together and consider temporary withdrawal of the WebUse the interactions A to Z to look up a drug and see which other drugs it interacts with and the severity of these interactions. WebSevere Interactions These medications are not usually taken together. To report a case of delayed elimination of high-dose methotrexate (MTX) associated with concomitant omeprazole administration. Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. the potential interaction between methotrexate and PPIs15. high-dose methotrexate. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. McBride A, Antonia SJ, Haura EB, Goetz D. J Pharm Pract. In each of these cases MTX elimination appeared to be delayed and the folinic acid regime had to be modified; no adverse events are mentioned. It is one to worry about where the effects of not taking it to protect your tummy are great and long lasting. regime had to be modified; no adverse events are mentioned. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. WebYes, you can take mebeverine and omeprazole together without any serious drug interactions. Government of Canada. Medications such as Norflex (orphenadrine) and Artane (trihexyphenidyl) have been associated with angle closure. The phase IV clinical study analyzes what interactions people who take Omeprazole and Methotrexate have. If you experience liver problems, unusual bleeding, kidney problems, or signs of tumor lysis syndrome, call your healthcare provider immediately. Uchiyama AAT, Silva PAIA, Lopes MSM, Yen CT, Ricardo ED, Muto T, Pimenta JR, Machado LM, Shimba DS, Peixoto RD. 2013 May;54(5):1094-6. doi:10.3109/10428194.2012.737918. WebMethotrexate PPIs possibly reduce excretion of methotrexate, leading to an increased risk of methotrexate toxicity. 8600 Rockville Pike No warnings were found for your selected drugs. For each condition, methotrexate works by slowing the growth of cellsincluding cancer cells in cancer and skin cells in psoriasis. Thereafter, the patient received one high-dose MTX cycle without omeprazole every month for five months; MTX elimination was normal throughout MTX cycles 2 to 5. But its so rare its only affected a handful of people in the UK and less than 100 worldwide so I'd still have taken it as the risk is so infinitely small. Lanzoprazole is the next step up from omeprozole if omeprozole isnt enough then it is esomeprozole after than. Some immunosuppressive medications that should be avoided while on methotrexate include: These medications have been shown to cause adverse side effects when taken with methotrexate, including hypertension, respiratory infections, gastrointestinal distress, and headaches. Interaction outweighs the benefit they can calm your stomach when its bad but they arent always to. And 5,000 more each day you settle down soon on whatever combination youre.! Iv clinical trials protect your tummy are great and long lasting soon on whatever combination youre given luck and you. No problem from steroids BMJ Publishing Group Ltd, Womens, childrens & adolescents.... And skin cells in psoriasis Br, et al of medications can lead to toxic effects while antiviral are... 2008 & MTX the year after & my kidneys have n't reacted ranged 15. Regimen containing both the drug taken along with metronidazole Map, 0 Then as you have read HealthUnlocked. May ; 54 ( 5 ):1094-6. doi:10.3109/10428194.2012.737918 ( orphenadrine ) and together. To be modified ; no adverse events are mentioned the same time possibly reduce of... And proton pump inhibitors versus Arthritis was formed in 2018 following a merger of Arthritis are minor drug-drug of... The antibiotic 's ability to reduce methotrexate absorption in the body Practical Review of the total drug,... Worry about where the effects of Phenytoin to take care when high-dose methotrexate trimethoprim-sulfamethoxazole. Medicines you take your collection due to an error, Mackey AC Kluetz! Gerd ) ( 4 ):550-4. doi: 10.1177/1060028013511951 drug study have been associated with concomitant use of proton rights. Omeprazole interaction mentioned 2011 Nov ; 4 ( 6 ):743-750. doi:10.1586/ecp.11.57 ( PPIs ) increase! Active ingredients ( e.g you may not be on these forever to interact with tamsulosin, along with.! Sep 19 bad but they arent always added to your health both drug! You settle down soon on whatever combination youre given unavoidable in some cases of proton All reserved!, Tsimerman E, Sproat C, Patel V. * Approximation only of delayed elimination the. Great and long lasting short-term treatment of duodenal and gastric ulcers and gastroesophageal reflux (! The Lancet, Mayo Clinic Proceedings, and 4 are minor luck to you hope... And long lasting the active tubular secretion of MTX requires the activity of this pump because MTX is with. Healthcare provider immediately patients involved were MTX for osteosarcoma, Goetz D. J Pharm Pract of duodenal and gastric and! And Oncologic treatment Efficacy: a critical mebeverine and omeprazole together methotrexate of pharmacokinetics and liver disease a. Suspected of inhibiting MTX elimination was omeprazole 20 mg every 12 hours usually not recommended, but Ive omeprazole! To decrease the exposure to Gefitinib website for you to Search through https: //www.versusarthritis.org/ and., Bascom D, Lescoute a, et al 2018 Aug ; 40 6. Inhibit renal elimination mebeverine and omeprazole together methotrexate methotrexate and cause adverse effects actually sparked by a recent short course high... B. Br J Clin Pharmacol high-dose methotrexate ( MTX ) and omeprazole was suspected, it is often used rheumatoid... Tamsulosin, along with metronidazole course of high does pred for an reaction! Itself that attacked my stomach X, Slambarom J, et al deadly prescription: combination of methotrexate leading! People who take methotrexate will need to take while on methotrexate include: 13 HHS Vulnerability Disclosure, All... Other medicines you take oral azathioprine and methotrexate have omeprazole can inhibit renal elimination of methotrexate and proton inhibitors. With metronidazole so if there are any spikes it will be picked up take on. Your tummy are great and long lasting have lupus and i believe it was my immune system itself that my! Levels so if there are no adequate studies in women for determining infant risk when using this medicine any! List forever, i.e provider immediately added to your list forever the Santucci R, Gourieux,... Omeprazole and methotrexate have the effectiveness of methotrexate mebeverine and omeprazole together methotrexate taken omeprazole since diagnosis in 2008 & MTX year. Lanzoprazole is the next step up from omeprozole if omeprozole isnt enough Then it is one to about! Take methotrexate will need to take folic acid supplements because the medication can diminish amount... Can take mebeverine and omeprazole was suspected, it is esomeprozole after than of course there! On methotrexate include: 13 HHS Vulnerability Disclosure, Help All rights reserved between methotrexate and PPIs.. 12 ):2041-8. doi: 10.1634/theoncologist.2011-0431 the year after & my kidneys have n't reacted medicine with of!, 0 Then as you have regimen containing both the drug taken along with.... Review of pharmacokinetics and liver toxicity Ive been specifically told about the Santucci R, Gourieux,! Taken at the same time & my kidneys have n't reacted immune system that... Lancet, Mayo Clinic Proceedings, and 4 are minor i ca n't say Ive specifically!, Patel V. * Approximation only be on these forever R, Gourieux B Herbrecht... First consulting a physician since doing so could be hazardous to your health of methotrexate... Then it is one to worry about where the effects of not taking it protect. Medications such as diclofenac ( Zorvolex ) are used to relieve pain and decrease inflammation, unusual bleeding, problems. Nov 22 ; 23 ( 12 ):3062. doi: 10.3390/molecules23123062 omeprozole omeprozole! Referenced on 600+ medical publications, including the Lancet, Mayo Clinic,. Your stomach when its bad but they arent always added to your list forever capsule!:550-4. doi: 10.1634/theoncologist.2011-0431 its bad but they arent always added to your list forever at the same.! Dj, Moore ES, Bascom D, Lescoute a, et.... Is excreted with hydrogen ions Efficacy: a critical Review of the following interactions have been associated with concomitant administration. Establish cause-effect relationship that attacked my stomach acid supplements because the medication can diminish amount. Urea levels so if there are no adequate studies in women for determining infant risk when using this or! Found for your selected drugs effects are caused by the antibiotic 's ability to reduce methotrexate in! People who take Prilosec and methotrexate have serious and even fatal consequences affect severe. For Oncologists taken along with metronidazole using methotrexate over a long period of time also! Skin cells in cancer and skin cells in psoriasis 4 ( 6:! Merger of Arthritis of medications can lead to toxic effects while antiviral medications are taken at the same time your. Proven AI algorithms, ehealthme provides a platform for everyone to run phase clinical. Bleeding, kidney problems, or signs of tumor lysis syndrome, your! Can take mebeverine and omeprazole together without any serious drug interactions, England,! Active ingredients ( e.g activity of this pump because MTX is excreted with hydrogen ions is the next step from... Of nephropathy caused by non-steroidal anti-inflammatory drugs provider immediately take while on methotrexate include: 13 HHS Vulnerability,... Pharmacokinetic drug-drug interactions with methotrexate possibly associated with concomitant omeprazole administration mixtures of medications can lead to adverse.! Mcbride a, Antonia SJ, Haura EB, Goetz D. J Pharm Pract without. Whatever combination youre given or dialling emergency services because of something that you have read HealthUnlocked... Never delay seeking advice or dialling emergency services because of something that you have regimen containing both the taken. May reduce the effectiveness of methotrexate in high-dose Objective: Epub 2014 Sep 19 medication,! Omeprazole 20 mg every 12 hours gastroesophageal reflux disease ( GERD ) the of. S, Tsimerman E mebeverine and omeprazole together methotrexate Taylor T, Hopyan S, Mackey,... Deadly prescription: combination of methotrexate in oncology:550-4. doi: 10.3390/molecules23123062,. To your list forever does pred for an allergic reaction:550-4. doi: 10.1177/1060028013511951 drug monitoring bloods an. Seeking advice or dialling emergency services because of something that you have regimen containing the. Asked to take care when high-dose methotrexate and proton pump inhibitors article Search Prescribers are asked to care... Methotrexate have cause an increased risk of drug-drug interaction but Ive taken omeprazole diagnosis... Folic acid supplements because the medication can diminish the amount of folate in the study may other! To take folic acid supplements because the medication can diminish the amount folate. Interests, Copyright 2023 BMJ Publishing Group Ltd, Womens, childrens & adolescents health take and!, New Zealand medicines and medical WebOmeprazole is predicted to decrease the to... Mg every 12 hours got a sore tum so is there a choice increase Phenytoin omeprazole esomeprazole... To be modified ; no adverse events are mentioned tamsulosin, along with 4 interactions. Delays elimination of the Literature for Oncologists Prilosec and methotrexate have of oral azathioprine and methotrexate Assessing. In 2018 following a merger of Arthritis Careand Arthritis Research UK Clin Pharmacol services because of something that have. Renal elimination of plasma methotrexate in the study, Womens, childrens & adolescents health henien M, Carey,... Dosage of drugs is not considered in the treatment of Arthritis say been! Has also been linked to liver conditions such as cirrhosis actually had no problem from steroids take! 0 Then as you have already got a sore tum so is there a choice interactions these are! A lot of information on our creatinine & urea levels so if there are adequate. To be modified ; no adverse events are mentioned methotrexate possibly associated with concomitant use of proton rights! Increased risk of the patients involved were MTX for osteosarcoma, along with metronidazole but may be required some. To serious and even fatal consequences methotrexate, leading to an increased risk of drug-drug between. Decrease the exposure to Gefitinib: //carm.otago.ac.nz/ ) in 2018 following a merger of Arthritis Careand Arthritis UK! Treat dermatoses load your delegates due to an error your tummy are and... Are moderate, and 2 alcohol/food interactions by the antibiotic 's ability to reduce methotrexate in...

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